Company Description
Silence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications.
The company's platform includes mRNAi GalNAc Oligonucleotide Discovery platform designed to accurately target specific disease-associated genes in the liver.
It designs short interfering RNA molecules to harness the body's natural mechanism of RNA interference, and degrading messenger RNA molecules that encode specific targeted disease-associated proteins in a cell.
The company is developing various product candidates, including SLN360, which is Phase I clinical trials for the treatment of cardiovascular disease with high lipoprotein; SLN124 that is in Phase I clinical trials for the treatment of non-transfusion dependent thalassemia, and Phase I clinical trials for the treatment of myelodysplastic syndrome; and SLN124 for the treatment of polycythemia vera.
It has collaboration agreements with AstraZeneca PLC to discover, develop, and commercialize small interfering RNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; and Mallinckrodt Pharma IP Trading DAC to develop and commercialize RNAi drug targets designed to silence the complement cascade in complement-mediated disorders.
The company also has a collaboration with Hansoh Pharmaceutical Group Company Limited to develop siRNAs for three undisclosed targets leveraging Silence's mRNAi GOLD platform.
The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007.
Silence Therapeutics plc is headquartered in London, the United Kingdom.
| Country | GB |
| IPO Date | Sep 8, 2020 |
| Industry | Biotechnology |
| Sector | Healthcare |
| Employees | 109 |
| CEO | Craig A. Tooman M.B.A. |
Contact Details
Address: 72 Hammersmith Road London, GB | |
| Website | https://www.silence-therapeutics.com |
Stock Details
| Ticker Symbol | SLN |
| Exchange | NASDAQ |
| Fiscal Year | January - December |
| Reporting Currency | USD |
| CIK Code | 0001479615 |
| CUSIP Number | 82686Q101 |
| ISIN Number | US82686Q1013 |
| Employer ID | 00-0000000 |
| SIC Code | 2834 |
Key Executives
| Name | Position |
|---|---|
| Craig A. Tooman M.B.A. | President, Chief Executive Officer & Executive Director |
| Rhonda L. Hellums | Executive Vice President, Chief Financial Officer & Secretary |
| Curtis Rambaran M.D. | Chief Medical Officer |
| Dr. Barbara A. Ruskin J.D., Ph.D. | Senior Vice President and Chief Intellectual Property & Innovation Officer |
| Dr. Eric Floyd M.B.A., M.S., Ph.D. | Senior Vice President of Regulatory Affairs & Quality Assurance |
| Dr. Marie Wikstrom Lindholm Ph.D. | Chief Scientific Officer |
| Dr. Steven J. Romano M.D. | Executive Vice President and Chief Research & Development Officer |
| Gem Gokmen Hopkins | Head of IR & Corporate Communications |
| Gianine Esposito | Chief Human Resources Officer |
| J.P. Gabriel | Chief Technical Operations Officer |
Latest SEC Filings
| Date | Type | Title |
|---|---|---|
| Dec 09, 2024 | 6-K | Filing |
| Nov 18, 2024 | 6-K | Filing |
| Nov 14, 2024 | SC 13G/A | [Amend] Statement of acquisition of beneficial own... |
| Nov 14, 2024 | SC 13G/A | [Amend] Statement of acquisition of beneficial own... |
| Nov 14, 2024 | 6-K | Filing |
| Nov 12, 2024 | SC 13G/A | [Amend] Statement of acquisition of beneficial own... |
| Oct 22, 2024 | F-3ASR | Filing |
| Aug 15, 2024 | 6-K | Filing |
| Aug 02, 2024 | SC 13G/A | [Amend] Statement of acquisition of beneficial own... |
| Jun 27, 2024 | 6-K | Filing |