SPDR S&P Biotech ETF (XBI)
AMEX: XBI
· Real-Time Price · USD
91.03
1.11 (1.23%)
At close: Aug 22, 2025, 1:48 PM
XBI Holdings List
As of Aug 22, 2025
The SPDR S&P Biotech ETF is an equity ETF with a total of 126 individual holdings.
The top holdings are Alnylam Pharmaceuticals at 3.60%, Insmed Incorporated at 3.10%, Halozyme Therapeutics at 3.10%, Incyte at 2.93%, and Regeneron Pharmaceuticals at 2.67%.
126
28.06%
Equity
5.05B
n/a
0.3500%
Sector Allocation
| Rank | Symbol | Name | Price | % Change | Shares | % Weight |
|---|---|---|---|---|---|---|
| 1 | ALNY | Alnylam Pharmac... | 458.33 | -1.97% | 401.64K | 3.60% |
| 2 | INSM | Insmed Incorpor... | 131.68 | -0.69% | 1.22M | 3.10% |
| 3 | HALO | Halozyme Therap... | 71.58 | -0.05% | 2.23M | 3.10% |
| 4 | INCY | Incyte Corporat... | 85.51 | -1.18% | 1.74M | 2.93% |
| 5 | REGN | Regeneron Pharm... | 595.28 | -0.48% | 231.24K | 2.67% |
| 6 | UTHR | United Therapeu... | 314.60 | +1.27% | 433.71K | 2.60% |
| 7 | ABBV | AbbVie Inc. | 209.37 | -0.06% | 626.25K | 2.56% |
| 8 | GILD | Gilead Sciences... | 115.12 | -0.88% | 1.1M | 2.54% |
| 9 | NBIX | Neurocrine Bios... | 135.10 | -0.13% | 965.79K | 2.51% |
| 10 | BIIB | Biogen Inc. | 139.21 | +0.06% | 901.25K | 2.45% |
| 11 | AMGN | Amgen Inc. | 294.46 | -0.44% | 410.91K | 2.38% |
| 12 | BMRN | BioMarin Pharma... | 58.10 | +0.05% | 2.1M | 2.38% |
| 13 | BBIO | BridgeBio Pharm... | 49.20 | -2.05% | 2.45M | 2.35% |
| 14 | MDGL | Madrigal Pharma... | 408.55 | +0.36% | 306.21K | 2.34% |
| 15 | MRNA | Moderna, Inc. | 27.23 | +3.84% | 4.32M | 2.27% |
| 16 | NTRA | Natera, Inc. | 164.64 | +1.66% | 719.18K | 2.26% |
| 17 | EXEL | Exelixis, Inc. | 38.45 | -0.68% | 2.89M | 2.14% |
| 18 | VRTX | Vertex Pharmace... | 396.83 | -0.16% | 265.13K | 2.04% |
| 19 | EXAS | Exact Sciences ... | 47.52 | +1.81% | 2.15M | 1.98% |
| 20 | ROIV | Roivant Science... | 11.90 | +0.80% | 7.37M | 1.69% |
| 21 | CYTK | Cytokinetics, I... | 38.71 | +1.73% | 2.11M | 1.54% |
| 22 | IONS | Ionis Pharmaceu... | 42.18 | -2.45% | 1.81M | 1.51% |
| 23 | CRSP | CRISPR Therapeu... | 54.13 | +2.49% | 1.43M | 1.48% |
| 24 | RNA | Avidity Bioscie... | 46.95 | +5.13% | 1.58M | 1.37% |
| 25 | RVMD | Revolution Medi... | 37.22 | +2.03% | 1.91M | 1.35% |
| 26 | TGTX | TG Therapeutics... | 29.18 | +1.43% | 2.35M | 1.30% |
| 27 | PCVX | Vaxcyte, Inc. | 32.46 | +1.72% | 2.06M | 1.26% |
| 28 | SMMT | Summit Therapeu... | 26.79 | +3.01% | 2.48M | 1.25% |
| 29 | RYTM | Rhythm Pharmace... | 104.62 | +2.90% | 644.04K | 1.24% |
| 30 | KRYS | Krystal Biotech... | 149.08 | +2.32% | 432.55K | 1.23% |
| 31 | PTCT | PTC Therapeutic... | 50.31 | +2.85% | 1.22M | 1.16% |
| 32 | ALKS | Alkermes plc | 29.85 | +2.72% | 2.01M | 1.14% |
| 33 | ADMA | ADMA Biologics,... | 17.66 | +3.30% | 3.32M | 1.12% |
| 34 | PTGX | Protagonist The... | 57.47 | +2.55% | 1M | 1.10% |
| 35 | AKRO | Akero Therapeut... | 48.72 | +0.89% | 1.16M | 1.09% |
| 36 | VKTX | Viking Therapeu... | 26.41 | +2.93% | 1.97M | 0.99% |
| 37 | ACLX | Arcellx, Inc. | 71.72 | -0.07% | 703.46K | 0.98% |
| 38 | APLS | Apellis Pharmac... | 27.83 | +0.77% | 1.8M | 0.93% |
| 39 | NUVL | Nuvalent, Inc. | 75.85 | +2.98% | 603.74K | 0.86% |
| 40 | SRRK | Scholar Rock Ho... | 35.18 | +1.70% | 1.25M | 0.84% |
| 41 | SLNO | Soleno Therapeu... | 69.08 | -1.03% | 591.48K | 0.80% |
| 42 | VCYT | Veracyte, Inc. | 31.09 | +5.64% | 1.36M | 0.78% |
| 43 | ACAD | ACADIA Pharmace... | 25.65 | +3.49% | 1.57M | 0.77% |
| 44 | FOLD | Amicus Therapeu... | 7.62 | +0.20% | 5.18M | 0.75% |
| 45 | SRPT | Sarepta Therape... | 19.56 | -2.48% | 1.85M | 0.74% |
| 46 | ARWR | Arrowhead Pharm... | 21.46 | +3.42% | 1.77M | 0.70% |
| 47 | IDYA | IDEAYA Bioscien... | 25.18 | +2.23% | 1.37M | 0.65% |
| 48 | CRNX | Crinetics Pharm... | 30.84 | +4.90% | 1.13M | 0.64% |
| 49 | BCRX | BioCryst Pharma... | 8.60 | +2.57% | 3.76M | 0.61% |
| 50 | MIRM | Mirum Pharmaceu... | 71.13 | +3.00% | 463.38K | 0.60% |
| 51 | ARQT | Arcutis Biother... | 16.00 | +1.31% | 1.93M | 0.59% |
| 52 | RARE | Ultragenyx Phar... | 29.70 | +0.61% | 1.01M | 0.58% |
| 53 | TVTX | Travere Therape... | 17.89 | +0.53% | 1.54M | 0.54% |
| 54 | NVAX | Novavax, Inc. | 7.85 | +2.88% | 3.16M | 0.54% |
| 55 | ARDX | Ardelyx, Inc. | 6.20 | +1.47% | 4.48M | 0.52% |
| 56 | CGON | CG Oncology, In... | 26.93 | +3.66% | 999.37K | 0.50% |
| 57 | TWST | Twist Bioscienc... | 28.34 | +7.08% | 944.39K | 0.49% |
| 58 | SNDX | Syndax Pharmace... | 15.95 | +0.67% | 1.57M | 0.48% |
| 59 | BEAM | Beam Therapeuti... | 16.62 | +3.80% | 1.53M | 0.48% |
| 60 | CPRX | Catalyst Pharma... | 20.95 | +1.87% | 1.19M | 0.47% |
| 61 | IRON | Disc Medicine, ... | 60.24 | +0.82% | 392.12K | 0.45% |
| 62 | AGIO | Agios Pharmaceu... | 39.05 | +2.22% | 615.35K | 0.44% |
| 63 | BHVN | Biohaven Ltd. | 15.63 | +6.47% | 1.51M | 0.43% |
| 64 | DNLI | Denali Therapeu... | 15.46 | +1.54% | 1.52M | 0.43% |
| 65 | RXRX | Recursion Pharm... | 5.01 | +4.81% | 4.45M | 0.41% |
| 66 | KYMR | Kymera Therapeu... | 44.03 | +3.38% | 499.9K | 0.41% |
| 67 | DVAX | Dynavax Technol... | 10.58 | -3.38% | 2.03M | 0.41% |
| 68 | VCEL | Vericel Corpora... | 36.50 | +2.99% | 591.43K | 0.41% |
| 69 | VERA | Vera Therapeuti... | 23.08 | +2.09% | 897.6K | 0.39% |
| 70 | IMVT | Immunovant, Inc... | 15.20 | +2.43% | 1.33M | 0.38% |
| 71 | APGE | Apogee Therapeu... | 38.38 | +5.57% | 525.76K | 0.37% |
| 72 | CLDX | Celldex Therape... | 22.65 | +2.86% | 891.27K | 0.36% |
| 73 | VRDN | Viridian Therap... | 19.21 | +6.60% | 951.82K | 0.34% |
| 74 | GRAL | GRAIL, Inc. | 34.12 | +2.93% | 511.05K | 0.32% |
| 75 | DYN | Dyne Therapeuti... | 12.48 | +2.17% | 1.37M | 0.32% |
| 76 | NTLA | Intellia Therap... | 10.54 | +4.05% | 1.6M | 0.32% |
| 77 | SPRY | ARS Pharmaceuti... | 13.79 | -7.3% | 1.01M | 0.29% |
| 78 | JANX | Janux Therapeut... | 24.59 | +2.46% | 584.42K | 0.28% |
| 79 | GERN | Geron Corporati... | 1.46 | +2.10% | 10.32M | 0.28% |
| 80 | PRAX | Praxis Precisio... | 47.55 | +2.53% | 308.99K | 0.27% |
| 81 | ETNB | 89bio, Inc. | 9.47 | +3.10% | 1.52M | 0.27% |
| 82 | COGT | Cogent Bioscien... | 12.27 | +4.21% | 1.14M | 0.27% |
| 83 | QURE | uniQure N.V. | 15.95 | +2.57% | 856.99K | 0.26% |
| 84 | RCUS | Arcus Bioscienc... | 10.56 | +0.81% | 1.23M | 0.24% |
| 85 | STOK | Stoke Therapeut... | 19.38 | -1.52% | 640.96K | 0.24% |
| 86 | MNKD | MannKind Corpor... | 4.04 | +2.41% | 2.93M | 0.23% |
| 87 | AVXL | Anavex Life Sci... | 9.66 | +1.15% | 1.15M | 0.22% |
| 88 | MLYS | Mineralys Thera... | 14.92 | +2.12% | 714.65K | 0.22% |
| 89 | VSTM | Verastem, Inc. | 9.31 | +7.94% | 1.31M | 0.21% |
| 90 | CDNA | CareDx, Inc | 12.84 | +2.63% | 888.89K | 0.21% |
| 91 | SYRE | Spyre Therapeut... | 17.43 | +3.87% | 634.7K | 0.20% |
| 92 | AKBA | Akebia Therapeu... | 3.23 | +1.39% | 3.16M | 0.19% |
| 93 | KROS | Keros Therapeut... | 15.48 | +2.04% | 676.22K | 0.19% |
| 94 | RIGL | Rigel Pharmaceu... | 41.81 | -0.43% | 228.01K | 0.18% |
| 95 | KURA | Kura Oncology, ... | 7.60 | +2.15% | 1.31M | 0.18% |
| 96 | IOVA | Iovance Biother... | 2.71 | +6.90% | 3.64M | 0.18% |
| 97 | IMNM | Immunome, Inc. | 10.45 | +5.03% | 951.68K | 0.18% |
| 98 | NRIX | Nurix Therapeut... | 10.10 | +4.66% | 943.13K | 0.18% |
| 99 | EBS | Emergent BioSol... | 9.51 | +1.98% | 970.38K | 0.17% |
| 100 | XNCR | Xencor, Inc. | 8.22 | +10.48% | 1.13M | 0.17% |
| 101 | DAWN | Day One Biophar... | 7.26 | +4.08% | 1.23M | 0.16% |
| 102 | DNTH | Dianthus Therap... | 23.91 | +1.10% | 355.25K | 0.16% |
| 103 | ARCT | Arcturus Therap... | 18.52 | +5.95% | 468.91K | 0.16% |
| 104 | MYGN | Myriad Genetics... | 6.01 | +3.07% | 1.41M | 0.15% |
| 105 | MTSR | Metsera, Inc. | 34.06 | +3.83% | 240.31K | 0.15% |
| 106 | RLAY | Relay Therapeut... | 3.70 | +8.50% | 2.27M | 0.15% |
| 107 | KALV | KalVista Pharma... | 13.44 | +3.70% | 584.17K | 0.15% |
| 108 | VIR | Vir Biotechnolo... | 4.54 | +3.65% | 1.64M | 0.14% |
| 109 | IBRX | ImmunityBio, In... | 2.31 | +3.12% | 3.14M | 0.14% |
| 110 | ANAB | AnaptysBio, Inc... | 20.37 | +0.05% | 334.15K | 0.13% |
| 111 | RGNX | REGENXBIO Inc. | 9.06 | +11.74% | 755.49K | 0.12% |
| 112 | MDXG | MiMedx Group, I... | 7.28 | +3.49% | 784.48K | 0.11% |
| 113 | REPL | Replimune Group... | 5.62 | +0.36% | 990.61K | 0.10% |
| 114 | ORIC | ORIC Pharmaceut... | 9.86 | +1.75% | 531.21K | 0.10% |
| 115 | ALT | Altimmune, Inc. | 3.58 | +1.42% | 1.27M | 0.09% |
| 116 | CAPR | Capricor Therap... | 7.02 | +0.07% | 597.23K | 0.08% |
| 117 | TSHA | Taysha Gene The... | 2.95 | +2.79% | 1.48M | 0.08% |
| 118 | ABUS | Arbutus Biophar... | 3.58 | +0.14% | 1.1M | 0.07% |
| 119 | AVBP | ArriVent BioPha... | 20.03 | +0.75% | 196.26K | 0.07% |
| 120 | HUMA | Humacyte, Inc. | 1.57 | +2.27% | 2.31M | 0.07% |
| 121 | CGEM | Cullinan Oncolo... | 8.19 | +6.76% | 488.52K | 0.07% |
| 122 | Ssi us gov mone... | n/a | n/a | 2.98M | 0.06% | |
| 123 | Contra inhibrx ... | n/a | n/a | 1.65M | 0.02% | |
| 124 | Contra mirati t... | n/a | n/a | 1.37M | 0.02% | |
| 125 | Contra verve th... | n/a | n/a | 900.27K | < 0.01% | |
| 126 | Contra blueprin... | n/a | n/a | 756.47K | < 0.01% |