SPDR S&P Biotech ETF (XBI)
AMEX: XBI
· Real-Time Price · USD
83.08
0.15 (0.18%)
At close: Jul 01, 2025, 3:59 PM
83.39
0.38%
After-hours: Jul 01, 2025, 07:13 PM EDT
XBI Holdings List
As of Jun 25, 2025
The SPDR S&P Biotech ETF holds 127 different assets
and the largest one in the portfolio is Exelixis, Inc., making up 2.66% of
the total.
| Rank | Symbol | Name | Price | % Change | Shares | % Weight |
|---|---|---|---|---|---|---|
| 1 | EXEL | Exelixis, Inc. | 43.62 | -1.03% | 2.88M | 2.66% |
| 2 | ALNY | Alnylam Pharmac... | 322.10 | -1.22% | 399.76K | 2.62% |
| 3 | INSM | Insmed Incorpor... | 97.64 | -2.98% | 1.22M | 2.60% |
| 4 | UTHR | United Therapeu... | 290.60 | +1.13% | 431.82K | 2.52% |
| 5 | NBIX | Neurocrine Bios... | 127.97 | +1.81% | 961.39K | 2.48% |
| 6 | NTRA | Natera, Inc. | 161.13 | -4.62% | 715.92K | 2.48% |
| 7 | REGN | Regeneron Pharm... | 534.94 | +1.89% | 230.21K | 2.42% |
| 8 | INCY | Incyte Corporat... | 68.72 | +0.91% | 1.73M | 2.41% |
| 9 | HALO | Halozyme Therap... | 52.88 | +1.65% | 2.22M | 2.41% |
| 10 | VRTX | Vertex Pharmace... | 452.42 | +1.62% | 263.86K | 2.40% |
| 11 | GILD | Gilead Sciences... | 111.74 | +0.78% | 1.09M | 2.36% |
| 12 | ABBV | AbbVie Inc. | 189.85 | +2.28% | 623.46K | 2.33% |
| 13 | MRNA | Moderna, Inc. | 28.70 | +4.01% | 4.3M | 2.32% |
| 14 | BMRN | BioMarin Pharma... | 56.10 | +2.06% | 2.09M | 2.30% |
| 15 | AMGN | Amgen Inc. | 290.58 | +4.07% | 409.1K | 2.29% |
| 16 | BIIB | Biogen Inc. | 129.98 | +3.50% | 897.23K | 2.29% |
| 17 | EXAS | Exact Sciences ... | 54.59 | +2.73% | 2.14M | 2.21% |
| 18 | BBIO | BridgeBio Pharm... | 42.78 | -0.93% | 2.44M | 2.19% |
| 19 | BPMC | Blueprint Medic... | 128.35 | +0.13% | 752.17K | 1.95% |
| 20 | TGTX | TG Therapeutics... | 35.41 | -1.6% | 2.34M | 1.76% |
| 21 | MDGL | Madrigal Pharma... | 299.66 | -0.98% | 304.66K | 1.75% |
| 22 | ROIV | Roivant Science... | 10.93 | -3.02% | 7.34M | 1.71% |
| 23 | RVMD | Revolution Medi... | 36.91 | +0.31% | 1.9M | 1.53% |
| 24 | IONS | Ionis Pharmaceu... | 39.95 | +1.11% | 1.8M | 1.44% |
| 25 | CYTK | Cytokinetics, I... | 33.65 | +1.83% | 2.1M | 1.42% |
| 26 | PCVX | Vaxcyte, Inc. | 32.90 | +1.18% | 2.05M | 1.41% |
| 27 | SWTX | SpringWorks The... | 46.99 | +0.02% | 1.42M | 1.34% |
| 28 | CRSP | CRISPR Therapeu... | 48.48 | -0.32% | 1.42M | 1.34% |
| 29 | AKRO | Akero Therapeut... | 51.41 | -3.65% | 1.16M | 1.26% |
| 30 | KRYS | Krystal Biotech... | 139.04 | +1.15% | 430.44K | 1.25% |
| 31 | PTCT | PTC Therapeutic... | 48.60 | -0.49% | 1.21M | 1.21% |
| 32 | ADMA | ADMA Biologics,... | 17.89 | -1.76% | 3.3M | 1.19% |
| 33 | ALKS | Alkermes plc | 28.99 | +1.33% | 2M | 1.19% |
| 34 | PTGX | Protagonist The... | 50.30 | -8.99% | 1M | 1.08% |
| 35 | VKTX | Viking Therapeu... | 26.67 | +0.64% | 1.96M | 1.06% |
| 36 | SMMT | Summit Therapeu... | 21.14 | -0.63% | 2.47M | 1.04% |
| 37 | SLNO | Soleno Therapeu... | 82.65 | -1.35% | 588.64K | 1.00% |
| 38 | RNA | Avidity Bioscie... | 28.43 | +0.11% | 1.58M | 0.95% |
| 39 | NUVL | Nuvalent, Inc. | 78.05 | +2.29% | 600.88K | 0.93% |
| 40 | ACLX | Arcellx, Inc. | 64.76 | -1.66% | 700K | 0.89% |
| 41 | SRRK | Scholar Rock Ho... | 33.75 | -4.71% | 1.24M | 0.83% |
| 42 | RYTM | Rhythm Pharmace... | 65.55 | +3.73% | 640.91K | 0.82% |
| 43 | RARE | Ultragenyx Phar... | 36.26 | -0.28% | 1.01M | 0.75% |
| 44 | BCRX | BioCryst Pharma... | 9.02 | +0.61% | 3.74M | 0.75% |
| 45 | VCYT | Veracyte, Inc. | 27.30 | +1.00% | 1.35M | 0.73% |
| 46 | ACAD | ACADIA Pharmace... | 21.30 | -1.23% | 1.56M | 0.70% |
| 47 | CRNX | Crinetics Pharm... | 28.39 | -1.27% | 1.13M | 0.70% |
| 48 | SRPT | Sarepta Therape... | 17.69 | +3.45% | 1.84M | 0.70% |
| 49 | TWST | Twist Bioscienc... | 36.78 | -0.03% | 939.39K | 0.68% |
| 50 | APLS | Apellis Pharmac... | 17.86 | +3.15% | 1.79M | 0.67% |
| 51 | IDYA | IDEAYA Bioscien... | 21.13 | +0.52% | 1.36M | 0.60% |
| 52 | FOLD | Amicus Therapeu... | 5.83 | +1.83% | 5.15M | 0.59% |
| 53 | ARWR | Arrowhead Pharm... | 16.11 | +1.99% | 1.76M | 0.57% |
| 54 | ARQT | Arcutis Biother... | 13.77 | -1.75% | 1.92M | 0.55% |
| 55 | CPRX | Catalyst Pharma... | 21.18 | -2.42% | 1.19M | 0.53% |
| 56 | BEAM | Beam Therapeuti... | 17.50 | +2.91% | 1.53M | 0.53% |
| 57 | CGON | CG Oncology, In... | 26.36 | +1.38% | 996.26K | 0.52% |
| 58 | VCEL | Vericel Corpora... | 41.59 | -2.26% | 589.51K | 0.52% |
| 59 | MIRM | Mirum Pharmaceu... | 48.41 | -4.87% | 461.88K | 0.48% |
| 60 | KYMR | Kymera Therapeu... | 44.41 | +1.76% | 498.44K | 0.47% |
| 61 | TVTX | Travere Therape... | 14.73 | -0.47% | 1.54M | 0.47% |
| 62 | RXRX | Recursion Pharm... | 5.12 | +1.19% | 4.42M | 0.47% |
| 63 | APGE | Apogee Therapeu... | 44.31 | +2.03% | 524.2K | 0.46% |
| 64 | GRAL | GRAIL, Inc. | 49.23 | -4.26% | 509.55K | 0.45% |
| 65 | BHVN | Biohaven Ltd. | 13.94 | -1.2% | 1.51M | 0.45% |
| 66 | DNLI | Denali Therapeu... | 13.91 | -0.54% | 1.52M | 0.44% |
| 67 | IRON | Disc Medicine, ... | 51.09 | -3.52% | 390.98K | 0.43% |
| 68 | IMVT | Immunovant, Inc... | 16.16 | +1.00% | 1.32M | 0.43% |
| 69 | AGIO | Agios Pharmaceu... | 34.39 | +3.40% | 613.5K | 0.41% |
| 70 | NVAX | Novavax, Inc. | 6.61 | +4.84% | 3.15M | 0.41% |
| 71 | VERA | Vera Therapeuti... | 22.98 | -2.46% | 895.01K | 0.41% |
| 72 | DVAX | Dynavax Technol... | 10.05 | +1.36% | 2.02M | 0.40% |
| 73 | CLDX | Celldex Therape... | 21.25 | +4.40% | 888.63K | 0.39% |
| 74 | SPRY | ARS Pharmaceuti... | 16.07 | -7.94% | 1M | 0.34% |
| 75 | CDNA | CareDx, Inc | 18.84 | -3.61% | 886.28K | 0.34% |
| 76 | ARDX | Ardelyx, Inc. | 3.90 | -0.38% | 4.46M | 0.33% |
| 77 | GERN | Geron Corporati... | 1.39 | -1.77% | 10.29M | 0.32% |
| 78 | NTLA | Intellia Therap... | 9.81 | +4.58% | 1.6M | 0.31% |
| 79 | ETNB | 89bio, Inc. | 9.75 | -0.71% | 1.52M | 0.30% |
| 80 | DYN | Dyne Therapeuti... | 8.67 | -8.93% | 1.37M | 0.29% |
| 81 | SNDX | Syndax Pharmace... | 8.83 | -5.71% | 1.57M | 0.29% |
| 82 | VRDN | Viridian Therap... | 14.47 | +3.54% | 948.81K | 0.28% |
| 83 | JANX | Janux Therapeut... | 23.19 | +0.39% | 582.83K | 0.27% |
| 84 | PRAX | Praxis Precisio... | 43.13 | +2.57% | 308.01K | 0.27% |
| 85 | QURE | uniQure N.V. | 13.96 | +0.11% | 854.29K | 0.24% |
| 86 | MNKD | MannKind Corpor... | 3.58 | -4.41% | 2.92M | 0.23% |
| 87 | AKBA | Akebia Therapeu... | 3.56 | -2.34% | 3.15M | 0.23% |
| 88 | NRIX | Nurix Therapeut... | 11.70 | +2.72% | 940.38K | 0.23% |
| 89 | AVXL | Anavex Life Sci... | 9.31 | +1.03% | 1.14M | 0.22% |
| 90 | RCUS | Arcus Bioscienc... | 8.37 | +2.76% | 1.23M | 0.22% |
| 91 | VERV | Verve Therapeut... | 11.28 | +0.45% | 934.24K | 0.21% |
| 92 | MLYS | Mineralys Thera... | 13.69 | +1.15% | 712.47K | 0.20% |
| 93 | SYRE | Spyre Therapeut... | 15.51 | +3.57% | 632.89K | 0.20% |
| 94 | REPL | Replimune Group... | 9.13 | -1.72% | 987.72K | 0.19% |
| 95 | XNCR | Xencor, Inc. | 8.05 | +2.42% | 1.13M | 0.19% |
| 96 | KROS | Keros Therapeut... | 13.34 | -0.11% | 674.26K | 0.19% |
| 97 | ALT | Altimmune, Inc. | 4.20 | +8.53% | 1.27M | 0.18% |
| 98 | IBRX | ImmunityBio, In... | 2.57 | -2.65% | 3.14M | 0.18% |
| 99 | VIR | Vir Biotechnolo... | 5.10 | +1.19% | 1.64M | 0.17% |
| 100 | IMNM | Immunome, Inc. | 8.49 | -8.66% | 948.76K | 0.17% |
| 101 | COGT | Cogent Bioscien... | 7.20 | +0.28% | 1.14M | 0.17% |
| 102 | DAWN | Day One Biophar... | 6.62 | +1.77% | 1.23M | 0.16% |
| 103 | ANAB | AnaptysBio, Inc... | 22.59 | +1.76% | 333.16K | 0.16% |
| 104 | KURA | Kura Oncology, ... | 5.59 | -3.12% | 1.31M | 0.16% |
| 105 | RLAY | Relay Therapeut... | 3.52 | +1.88% | 2.26M | 0.15% |
| 106 | STOK | Stoke Therapeut... | 11.64 | +2.56% | 638.96K | 0.15% |
| 107 | MYGN | Myriad Genetics... | 5.54 | +4.43% | 1.4M | 0.14% |
| 108 | MTSR | Metsera, Inc. | 26.88 | -5.52% | 239.57K | 0.14% |
| 109 | IOVA | Iovance Biother... | 1.75 | +1.45% | 3.63M | 0.14% |
| 110 | KALV | KalVista Pharma... | 11.59 | +2.48% | 582.43K | 0.14% |
| 111 | EBS | Emergent BioSol... | 6.57 | +2.90% | 967.45K | 0.13% |
| 112 | DNTH | Dianthus Therap... | 17.92 | -3.81% | 354.21K | 0.13% |
| 113 | RGNX | REGENXBIO Inc. | 8.26 | +0.55% | 753.29K | 0.13% |
| 114 | ARCT | Arcturus Therap... | 13.01 | -0.08% | 467.52K | 0.13% |
| 115 | VSTM | Verastem, Inc. | 4.29 | +3.25% | 1.3M | 0.12% |
| 116 | ORIC | ORIC Pharmaceut... | 10.12 | -0.3% | 529.57K | 0.11% |
| 117 | CAPR | Capricor Therap... | 9.66 | -2.72% | 595.4K | 0.11% |
| 118 | HUMA | Humacyte, Inc. | 2.27 | +8.85% | 2.3M | 0.10% |
| 119 | MDXG | MiMedx Group, I... | 6.24 | +2.13% | 782.11K | 0.09% |
| 120 | AVBP | ArriVent BioPha... | 20.85 | -4.23% | 195.6K | 0.09% |
| 121 | Us dollar | n/a | n/a | 4.28M | 0.09% | |
| 122 | RIGL | Rigel Pharmaceu... | 18.71 | -0.11% | 227.29K | 0.09% |
| 123 | CGEM | Cullinan Oncolo... | 7.63 | +1.39% | 487.11K | 0.08% |
| 124 | ABUS | Arbutus Biophar... | 3.17 | +2.75% | 1.1M | 0.07% |
| 125 | TSHA | Taysha Gene The... | 2.35 | +1.73% | 1.47M | 0.07% |
| 126 | Contra inhibrx ... | n/a | n/a | 1.65M | 0.02% | |
| 127 | Contra mirati t... | n/a | n/a | 1.37M | 0.02% |